FORMULATION AND CHARACTERIZATION OF ASTAXANTHIN LOADED SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)

Aim and Objective: SNEDDS (Self Nano Emulsifying Drug Delivery System) is an isotropic mixture of oil, surfactant, co-surfactant which forms nanoemulsions spontaneously when comes in contact with gastric fluid thereby increasing the solubility active substances. Astaxanthin one substances having low so it suits well this nanoformulation. This study aims to formulate characterize SNEDDS.
 Methods: research a laboratory experimental using spontaneous emulsification method.
 Results: was made 3 formulations by ratio surfactants co-surfactants that were characterized produce transmittance value F1 91%, F2 90%, F3 95%, particle size 183.75 nm PDI 0.272, 195.25 0.341, 105.75 0.392. The entrapment efficiency (%EE) Astaxanthine found be as follows; F1, F2, had 94.62, 94.35, 95.57% EE respectively. results showed surfactant concentration 72% 18% best formula forming Conclusion: It can concluded higher concentration, greater its ability reduce interfacial tension oil droplets obtain small sizes high values.
 
 Peer Review History: Received: 1 May 2022; Revised: 9 June; Accepted: 25 June, Available online: 15 July 2022
 Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, [email protected]
 UJPR follows most transparent toughest ‘Advanced OPEN peer review’ system. identity authors and, reviewers will known each other. process help eradicate any possible malicious/purposeful interference person (publishing staff, reviewer, editor, author, etc) during review. As result unique system, all get their due recognition respect, once names are published papers. We expect that, publishing review reports papers, helpful many for drafting article according specifications. Auhors remove error they improve article(s) previous displayed article(s). main purpose ‘to quality candidate manuscript’. Our check ‘strength weakness manuscript honestly’. There increase perfection, transparency. Received file: Reviewer's Comments:
 Average marks at initial stage: 5.0/10
 publication 7.0/10
 Reviewers:
 Sally A. El-Zahaby, Pharos University Alexandria, Egypt, [email protected]
 Mohamed Salama, Modern Technology & Information, [email protected]